Endocrine Abstracts

Background: Elevated plasma concentrations of apoB-lipoproteins (i.e. hyperapoB) is an independent predictor of type 2 diabetes (T2D) in humans; however underlying mechanisms remain unclear. Chronic reduction in the function of white adipose tissue (WAT) promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL, the most common form of apoB-lipoproteins, induce their dysfunction, measured as decreased hydrolysis and storage of t...